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Genes Dev. 2008 Oct 1;22(19):2639-44. doi: 10.1101/gad.484108.

Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion.

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1
INSERM, U860, Montpellier, F-34298 France.

Abstract

We describe here the role of histone deacetylase 3 (HDAC3) in sister chromatid cohesion and the deacetylation of histone H3 Lys 4 (H3K4) at the centromere. HDAC3 knockdown induced spindle assembly checkpoint activation and sister chromatid dissociation. The depletion of Polo-like kinase 1 (Plk1) or Aurora B restored cohesion in HDAC3-depleted cells. HDAC3 was also required for Shugoshin localization at centromeres. Finally, we show that HDAC3 depletion results in the acetylation of centromeric H3K4, correlated with a loss of dimethylation at the same position. These findings provide a functional link between sister chromatid cohesion and the mitotic "histone code".

PMID:
18832068
PMCID:
PMC2559902
DOI:
10.1101/gad.484108
[Indexed for MEDLINE]
Free PMC Article
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