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FEBS Lett. 2008 Oct 29;582(25-26):3569-76. doi: 10.1016/j.febslet.2008.09.042. Epub 2008 Oct 1.

Mitochondria and L-lactate metabolism.

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  • 1Dipartimento di Scienze per la Salute, Universit√† del Molise, Via De Sanctis I-86100 Campobasso, Italy.


Although mitochondria have been the object of intensive study over many decades, some aspects of their metabolism remain to be fully elucidated, including the L-lactate metabolism. We review here the novel insights arisen from investigations on L-lactate metabolism in mammalian, plant and yeast mitochondria. The presence of L-lactate dehydrogenases inside mitochondria, where L-lactate enters in a carrier-mediated fashion, suggests that mitochondria play an important role in L-lactate metabolism. Functional studies have demonstrated the occurrence of several L-lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria.

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