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Clin Infect Dis. 2008 Nov 1;47(9):1222-5. doi: 10.1086/592304.

Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.

Author information

1
Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy.

Abstract

This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.

PMID:
18831695
PMCID:
PMC3672984
DOI:
10.1086/592304
[Indexed for MEDLINE]
Free PMC Article

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