Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2008 Nov 15;198(10):1550-3. doi: 10.1086/592715.

Plasma folate level and high-dose folate supplementation predict sulfadoxine-pyrimethamine treatment failure in pregnant women in Western kenya who have uncomplicated malaria.

Author information

1
Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. amvaneijk@yahoo.com

Abstract

Sulfadoxine-pyrimethamine (SP) inhibits folate metabolism by the malaria parasite. We investigated the association between folate levels and SP failure in pregnant women. Data from a trial to assess the effect that folate supplementation has on SP failure in 467 pregnant women were analyzed. Plasma folate levels were determined at enrollment and at day 7. High baseline folate levels, high parasite densities, and age <20 years were risk factors for SP failure. High-dose (5 mg daily) folate supplementation or high folate levels at day 7 were independent risk factors. Therefore, pregnant women receiving SP should receive low-/moderate-dose folate supplementation.

TRIAL REGISTRATION:

http://www.clinicaltrials.gov identifier: NCT00130065.

PMID:
18831691
DOI:
10.1086/592715
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center