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J Neurosci Res. 2009 Feb 15;87(3):599-608. doi: 10.1002/jnr.21890.

Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate?

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Perinatal Research Centre, University of Queensland Centre for Clinical Research, Herston, Queensland, Australia.


Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action.

[Indexed for MEDLINE]

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