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Parkinsonism Relat Disord. 2009 Jul;15(6):414-6. doi: 10.1016/j.parkreldis.2008.08.004. Epub 2008 Oct 1.

Glucosidase-beta variations and Lewy body disorders.

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1
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA. farrer.matthew@mayo.edu

Abstract

It has been proposed that there is an increased frequency of glucosidase-beta mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of glucosidase-beta mutations in 101 neuropathologically defined Lewy body disease cases (3%) compared to 99 healthy post-mortem controls (1%); odds ratio 3.0 (95% CI: 0.3-29, p=0.3). All three affected carriers were classified as diffuse Lewy body disease (n=3/50; 6%). Our study suggests glucosidase-beta variants have a limited role in susceptibility to Lewy body disease in North America.

PMID:
18829375
PMCID:
PMC2970615
DOI:
10.1016/j.parkreldis.2008.08.004
[Indexed for MEDLINE]
Free PMC Article
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