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Kidney Int. 2008 Oct;74(8):991-3. doi: 10.1038/ki.2008.442.

Animal models of sepsis and its complications.

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1
Logical Therapeutics Inc., Waltham, Massachusetts, USA. finkmp@ccm.upmc.edu

Abstract

Most currently used animal sepsis models fail to adequately replicate the clinical problem and, therefore, have only limited utility for investigating pathophysiological mechanisms or testing the efficacy of new therapeutic agents. Recent experimental findings support this view and suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.

PMID:
18827799
DOI:
10.1038/ki.2008.442
[Indexed for MEDLINE]
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