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J Thorac Oncol. 2008 Oct;3(10):1085-8. doi: 10.1097/JTO.0b013e3181886713.

Telomeres and telomerase in lung cancer.

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  • 1Oncology Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.

Abstract

Protected telomeres ensure normal chromosomal segregation during mitosis but at the same time can endow genetically abnormal cancer cells with immortality. Telomerase has a pivotal role in telomere protection, both in normal and cancer cells. Understanding the functional interplay between telomere shortening and telomerase expression in cancer cells is of critical importance to elucidating the precise mechanisms by which these cells are able to bypass telomere crisis and become immortal.

PMID:
18827602
DOI:
10.1097/JTO.0b013e3181886713
[PubMed - indexed for MEDLINE]
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