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Chem Pharm Bull (Tokyo). 2008 Oct;56(10):1483-5.

New Guaiane Sesquiterpenes from the Fruits of Torilis japonica.

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Division of Biotechnology, College of Environmental and Bioresources Sciences, Chonbuk National University, Jeonju, Korea.


Three new guaiane type sesquiterpenes were isolated from the methanolic extract of the fruits of Torilis japonica together with a known compound, torilin (1). Their structures were established as 11-acetoxy-8-isobutyryl-4-guaien-3-one (2), 11-acetoxy-8-methacrylyl-4-guaien-3-one (3), and 11-acetoxy-8-propionyl-4-guaien-3-one (4) by spectroscopic methods. These compounds inhibited lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages RAW 264.7 cells.

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