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Br J Psychiatry. 2008 Oct;193(4):316-21. doi: 10.1192/bjp.bp.107.045120.

Paternal age at birth and high-functioning autistic-spectrum disorder in offspring.

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1
Osaka Hamamatsu Joint Research Center for Child Mental Development (OHJRC-CMD), Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.

Abstract

BACKGROUND:

Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.

AIMS:

To test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability).

METHOD:

A case-control study was conducted in Japan. The participants consisted of individuals with full-scale IQ>or=70, with a DSM-IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order.

RESULTS:

Eighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates.

CONCLUSIONS:

Advanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.

PMID:
18827294
DOI:
10.1192/bjp.bp.107.045120
[Indexed for MEDLINE]
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