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Br J Psychiatry. 2008 Oct;193(4):311-5. doi: 10.1192/bjp.bp.107.045146.

Schizophrenia and offspring's risk for adverse pregnancy outcomes and infant death.

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1
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Emma.Nilsson@Socialstyrelsen.se

Abstract

BACKGROUND:

Women with schizophrenia are at increased risk for adverse pregnancy outcomes. It is not known whether offspring born to fathers with schizophrenia also have an increased risk.

AIMS:

To evaluate paternal and maternal influences on the association between schizophrenia and pregnancy outcomes.

METHOD:

A record linkage including 2 million births was made using Swedish population-based registers. The risk for adverse pregnancy outcomes was evaluated through logistic regression.

RESULTS:

Offspring with a mother or father with schizophrenia faced a doubled risk of infant mortality, which could not be explained by maternal behaviour alone during pregnancy. Excess infant death risk was largely attributable to post-neonatal death. Maternal factors (e.g. smoking) explained most of the other risks of adverse pregnancy outcomes among both mothers and fathers with schizophrenia.

CONCLUSIONS:

The risks to offspring whose fathers had schizophrenia suggest that, in addition to maternal risk behaviour, non-optimal social and/or parenting circumstances are of importance.

PMID:
18827293
DOI:
10.1192/bjp.bp.107.045146
[Indexed for MEDLINE]
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