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Bioinformatics. 2008 Dec 1;24(23):2782-3. doi: 10.1093/bioinformatics/btn510. Epub 2008 Sep 30.

MSX-3D: a tool to validate 3D protein models using mass spectrometry.

Author information

1
Institut de Biologie et Chimie des Protéines (IBCP) UMR5086 CNRS, Université Lyon 1, France.

Abstract

MOTIVATION:

The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking.

RESULTS:

We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment.

AVAILABILITY:

Freely available at http://proteomics-pbil.ibcp.fr

PMID:
18826958
DOI:
10.1093/bioinformatics/btn510
[Indexed for MEDLINE]
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