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Emerg Infect Dis. 2008 Oct;14(10):1637-40. doi: 10.3201/eid1410.080080.

Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

Author information

1
University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA.

Abstract

We conducted surveillance for multidrug-resistant Plasmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia near the Thai border, where artesunate-mefloquine therapy failures occur, contrasts with isolates from eastern Cambodia, where this combination therapy remains highly effective.

PMID:
18826834
PMCID:
PMC2609877
DOI:
10.3201/eid1410.080080
[Indexed for MEDLINE]
Free PMC Article

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