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J Infect Dis. 2008 Nov 15;198(10):1444-7. doi: 10.1086/592452.

Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccine.

Author information

1
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045-0508, USA. myron.levin@uchsc.edu

Abstract

A previously healthy boy who had received varicella vaccine developed herpes zoster with meningitis. The vaccine strain recovered from scabs of 3 skin lesions had the wild-type allele at position 108111, a vaccine marker never previously associated with vaccine-associated adverse events. The vaccine strain from cerebrospinal fluid also contained mutations never previously observed at vaccine-associated single nucleotide polymorphisms that would alter amino acid sequences in ORF54 and ORF59. The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster.

PMID:
18826373
DOI:
10.1086/592452
[Indexed for MEDLINE]

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