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Nano Lett. 2008 Nov;8(11):3692-5. doi: 10.1021/nl8018627. Epub 2008 Oct 1.

Nanoparticle self-assembly on a DNA-scaffold written by single-molecule cut-and-paste.

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Chair for Applied Physics, Ludwig-Maximilians-Universit├Ąt Munich, Amalienstrasse 54, 80799 Munich.


Self-assembly guided by molecular recognition has in the past been employed to assemble nanoparticle superstructures like hypercrystals or nanoparticle molecules. An alternative approach, the direct molecule-by-molecule assembly of nanoscale superstructures, was demonstrated recently. Here we present a hybrid approach where we first assemble a pattern of binding sites one-by-one at a surface and then allow different nanoparticles to attach by self-assembly. For this approach, biotin bearing DNA oligomers were picked up from a depot using a cDNA strand bound to an AFM tip. These units were deposited in the target area by hybridization, forming a recognition pattern on this surface. Fluorescent semiconductor nanoparticles conjugated with streptavidin were allowed to assemble on this scaffold and to form the final nanoparticle superstructures.

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