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Int J STD AIDS. 2008 Oct;19(10):680-4. doi: 10.1258/ijsa.2008.008040.

Human papillomavirus type-distribution in condylomata acuminata of mainland China: a meta-analysis.

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  • 1Department of Cancer Epidemiology, Cancer Institute, Peking Union Medical College, Beijing, China.

Abstract

The aim of this work was to study the human papillomavirus (HPV) type-distribution in condylomata acuminata (CA) of mainland China and to estimate the potential role of HPV prophylactic vaccines for CA in mainland China. Forty-three studies using polymerase chain reaction to detect HPV were included in this meta-analysis, and totally 5247 CA cases and 436 controls were included. The overall and type-specific prevalence of HPV 6, 11, 40, 42, 43, 44 were estimated using non-conditional logistic regression model. Overall HPV prevalence was 84.2% and 4.6% for CA and controls, respectively. Estimated HPV types 6, 11, 40, 42 positive fractions in CA were 54.9%, 41.1%, 2.7% and 2.0%, respectively, and exactly 0% for HPV types 43 and 44. HPV 6 and/or 11-positive fractions were 83.0% in mainland China. Thus, prophylactic HPV vaccine has the potential to protect up to 83% of CA cases in mainland China.

PMID:
18824620
DOI:
10.1258/ijsa.2008.008040
[PubMed - indexed for MEDLINE]
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