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Trends Plant Sci. 2008 Nov;13(11):567-73. doi: 10.1016/j.tplants.2008.08.005. Epub 2008 Sep 27.

L-Ascorbate biosynthesis in higher plants: the role of VTC2.

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  • 1Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract

In the past year, the last missing enzyme of the L-galactose pathway, the linear form of which appears to represent the major biosynthetic route to L-ascorbate (vitamin C) in higher plants, has been identified as a GDP-L-galactose phosphorylase. This enzyme catalyzes the first committed step in the synthesis of that vital antioxidant and enzyme cofactor. Here, we discuss how GDP-L-galactose phosphorylase enzymes, encoded in Arabidopsis by the paralogous VTC2 and VTC5 genes, function in concert with the other enzymes of the L-galactose pathway to provide plants with the appropriate levels of L-ascorbate. We hypothesize that regulation of L-ascorbate biosynthesis might occur at more than one step and warrants further investigation to allow for the manipulation of vitamin C levels in plants.

PMID:
18824398
PMCID:
PMC2583178
DOI:
10.1016/j.tplants.2008.08.005
[PubMed - indexed for MEDLINE]
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