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Trends Biochem Sci. 1991 May;16(5):173-7.

The TPR snap helix: a novel protein repeat motif from mitosis to transcription.

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  • 1Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122.


The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. These multi-domain proteins all contain tandemly arranged repeats of a 34-amino acid motif that are presumed to form helix-turn structures, each with a 'knob' and 'hole', acting as helix-associating domains.

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