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Ther Umsch. 2008 Oct;65(10):593-7. doi: 10.1024/0040-5930.65.10.593.

[Coronary heart disease and dyslipdemia - dosing recommendations at beginning and end of treatment].

[Article in German]

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Abteilung für Kardiologie, Angiologie und Pneumologie, Medizinische Klinik III, Universität Heidelberg.


Secondary prevention in patients with coronary heart disease includes treatment with platelet inhibitors, beta-blockers, ACE inhibitors or AT (1)-blockers, and statins. Initiation of therapy generally does not require a slow gradual dose increase. In treatment naive patients with acute coronary syndromes, administration of a loading dose of aspirin and/or clopidogrel is recommended. To reduce flushing, nicotinic acid should be initiated at low stepwise increasing dosages. beta-blocker therapy should not be stopped acutely in coronary heart disease patients. If beta-blocker therapy has to be terminated, blood pressure should be monitored closely and, if necessary controlled with other medication. Termination of statin therapy in the acute phase after strokes or acute coronary syndromes is associated with increased cardiovascular events and should therefore be avoided.

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