Abstract
Free fatty acids (FFAs) fuel physiological processes in various tissues, such as skeletal muscle, the heart, liver and pancreas. Malfunction of FFA-mediated signaling pathways, as well as FFA metabolism, has been correlated to pathologies such as type 2 diabetes and dyslipidemia. The recent deorphanization of the FFA receptor family has drawn attention to these G-protein-coupled receptors as potential therapeutic targets for the treatment of metabolic diseases.
MeSH terms
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Animals
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Diabetes Mellitus / drug therapy*
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Dyslipidemias / drug therapy*
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Fatty Acids, Nonesterified / metabolism*
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Humans
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Hypoglycemic Agents / pharmacology*
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Hypoglycemic Agents / therapeutic use*
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Hypolipidemic Agents / pharmacology*
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Hypolipidemic Agents / therapeutic use*
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Receptors, Cell Surface / drug effects
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Receptors, Cell Surface / metabolism*
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Receptors, G-Protein-Coupled / drug effects
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Receptors, G-Protein-Coupled / genetics
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Receptors, G-Protein-Coupled / metabolism
Substances
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Fatty Acids, Nonesterified
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Hypoglycemic Agents
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Hypolipidemic Agents
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Receptors, Cell Surface
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Receptors, G-Protein-Coupled