Free fatty acid receptor family: novel targets for the treatment of diabetes and dyslipidemia

Curr Opin Investig Drugs. 2008 Oct;9(10):1078-83.

Abstract

Free fatty acids (FFAs) fuel physiological processes in various tissues, such as skeletal muscle, the heart, liver and pancreas. Malfunction of FFA-mediated signaling pathways, as well as FFA metabolism, has been correlated to pathologies such as type 2 diabetes and dyslipidemia. The recent deorphanization of the FFA receptor family has drawn attention to these G-protein-coupled receptors as potential therapeutic targets for the treatment of metabolic diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / drug therapy*
  • Dyslipidemias / drug therapy*
  • Fatty Acids, Nonesterified / metabolism*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Hypoglycemic Agents / therapeutic use*
  • Hypolipidemic Agents / pharmacology*
  • Hypolipidemic Agents / therapeutic use*
  • Receptors, Cell Surface / drug effects
  • Receptors, Cell Surface / metabolism*
  • Receptors, G-Protein-Coupled / drug effects
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism

Substances

  • Fatty Acids, Nonesterified
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled