Format

Send to

Choose Destination
See comment in PubMed Commons below
J Autism Dev Disord. 2009 Feb;39(2):223-30. doi: 10.1007/s10803-008-0646-7. Epub 2008 Sep 23.

GABA(A) receptor downregulation in brains of subjects with autism.

Author information

1
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55455, USA. fatem002@umn.edu

Abstract

Gamma-aminobutyric acid A (GABA(A)) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABA(A) receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann's Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABA(A) receptor subunit expression in the three brain areas. Our results demonstrate that GABA(A) receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism.

PMID:
18821008
PMCID:
PMC2697059
DOI:
10.1007/s10803-008-0646-7
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center