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Clin Immunol. 2009 Jan;130(1):2-6. doi: 10.1016/j.clim.2008.08.011. Epub 2008 Sep 25.

NLRC4/IPAF: a CARD carrying member of the NLR family.

Author information

1
Inflammation Program, Department of Internal Medicine, University of Iowa, Iowa City, IA 52241, USA. fayyaz-sutterwala@uiowa.edu

Abstract

The NOD-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Recent findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria. Macrophages infected with Legionella pneumophila, Salmonella typhimurium, Shigella flexneri, or Pseudomonas aeruginosa activate caspase-1 in an NLRC4-dependent manner leading to macrophage cell death and the release of proinflammatory cytokines. This review will discuss these findings as well as the role of bacterial type III and type IV secretion systems and flagellin in NLRC4-mediated caspase-1 activation.

PMID:
18819842
PMCID:
PMC2630383
DOI:
10.1016/j.clim.2008.08.011
[Indexed for MEDLINE]
Free PMC Article
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