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Bioorg Med Chem Lett. 2008 Oct 15;18(20):5424-7. doi: 10.1016/j.bmcl.2008.09.039. Epub 2008 Sep 12.

A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity.

Author information

1
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece.

Abstract

A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (K(i) 21.8 microM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.

PMID:
18819796
PMCID:
PMC3712614
DOI:
10.1016/j.bmcl.2008.09.039
[Indexed for MEDLINE]
Free PMC Article

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