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Bioorg Med Chem Lett. 2008 Nov 15;18(22):6007-11. doi: 10.1016/j.bmcl.2008.09.019. Epub 2008 Sep 9.

Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs.

Author information

1
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.

Abstract

The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts-one originally identified from a catalyst screen (5) and its enantiomer (ent-5)-for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.

PMID:
18819795
PMCID:
PMC2669672
DOI:
10.1016/j.bmcl.2008.09.019
[Indexed for MEDLINE]
Free PMC Article

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