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J Neurol Sci. 2009 Jan 15;276(1-2):38-40. doi: 10.1016/j.jns.2008.08.025. Epub 2008 Sep 24.

Single dose of methylphenidate improves cognitive performance in multiple sclerosis patients with impaired attention process.

Author information

1
Lewenstein Rehabilitation Hospital, Raanana, Israel. yermih@clalit.org.il

Abstract

BACKGROUND AND PURPOSE:

Attention is one of the major cognitive domains adversely affected in multiple sclerosis (MS). The aim of the current study was to determine the effect of a single dose of methylphenidate on cognitive performance of MS patients with significant attention deficit.

METHODS:

In a double-blind placebo-controlled study design, 26 MS patients with impaired attention were randomly assigned to receive a single dose of 10 mg methylphenidate or placebo. Attention was assessed using the paced auditory serial addition test for 3 and 2 s (PASAT3'' and PASAT2'') at baseline and 1 h after drug/placebo administration.

RESULTS:

Methylphenidate significantly improved performance of both PASAT3'' and PASAT2'' tests by 22.8% and 25.6% respectively (p<0.001), while no significant changes were observed in placebo treated patients.

CONCLUSION:

Administration of a single dose of methylphenidate significantly improved attention in MS patients with considerable attention deficit.

PMID:
18817930
DOI:
10.1016/j.jns.2008.08.025
[Indexed for MEDLINE]

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