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Theor Popul Biol. 2008 Dec;74(4):291-301. doi: 10.1016/j.tpb.2008.08.003. Epub 2008 Sep 4.

Population differentiation and migration: coalescence times in a two-sex island model for autosomal and X-linked loci.

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  • 1Society of Fellows, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. sramach@fas.harvard.edu

Abstract

Evolutionists have debated whether population-genetic parameters, such as effective population size and migration rate, differ between males and females. In humans, most analyses of this problem have focused on the Y chromosome and the mitochondrial genome, while the X chromosome has largely been omitted from the discussion. Past studies have compared F(ST) values for the Y chromosome and mitochondrion under a model with migration rates that differ between the sexes but with equal male and female population sizes. In this study we investigate rates of coalescence for X-linked and autosomal lineages in an island model with different population sizes and migration rates for males and females, obtaining the mean time to coalescence for pairs of lineages from the same deme and for pairs of lineages from different demes. We apply our results to microsatellite data from the Human Genome Diversity Panel, and we examine the male and female migration rates implied by observed F(ST) values.

PMID:
18817799
PMCID:
PMC2630000
DOI:
10.1016/j.tpb.2008.08.003
[PubMed - indexed for MEDLINE]
Free PMC Article
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