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FEBS Lett. 2008 Oct 29;582(25-26):3577-84. doi: 10.1016/j.febslet.2008.08.038. Epub 2008 Sep 24.

D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1.

Author information

1
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA.

Abstract

Plants use sugars as signaling molecules and possess mechanisms to detect and respond to changes in sugar availability, ranging from the level of secondary signaling molecules to altered gene transcription. G-protein-coupled pathways are involved in sugar signaling in plants. The Arabidopsis thaliana regulator of G-protein signaling protein 1 (AtRGS1) combines a receptor-like seven transmembrane domain with an RGS domain, interacts with the Arabidopsis Galpha subunit (AtGPA1) in a d-glucose-regulated manner, and stimulates AtGPA1 GTPase activity. We determined that AtRGS1 interacts with additional components, genetically defined here, to serve as a plasma membrane sensor for d-glucose. This interaction between AtRGS1 and AtGPA1 involves, in part, the seven-transmembrane domain of AtRGS1.

PMID:
18817773
PMCID:
PMC2764299
DOI:
10.1016/j.febslet.2008.08.038
[Indexed for MEDLINE]
Free PMC Article

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