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Bioorg Med Chem Lett. 2008 Nov 15;18(22):5941-4. doi: 10.1016/j.bmcl.2008.09.043. Epub 2008 Sep 12.

Recent progress with FKBP-derived destabilizing domains.

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1
Department of Chemical and Systems Biology, Stanford University, 318 Campus Drive, Clark Center W350A, Stanford, CA 94305-5441, USA.

Abstract

The FKBP-derived destabilizing domains are increasingly being used to confer small molecule-dependent stability to many different proteins. The L106P domain confers instability to yellow fluorescent protein when it is fused to the N-terminus, the C-terminus, or spliced into the middle of yellow fluorescent protein, however multiple copies of L106P do not confer greater instability. These engineered destabilizing domains are not dominant to endogenous degrons that regulate protein stability.

PMID:
18815033
PMCID:
PMC2593907
DOI:
10.1016/j.bmcl.2008.09.043
[Indexed for MEDLINE]
Free PMC Article
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