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Ann Allergy Asthma Immunol. 2008 Sep;101(3):256-63. doi: 10.1016/S1081-1206(10)60490-5.

Racial disparities in asthma-related health outcomes in severe or difficult-to-treat asthma.

Author information

1
Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. haselkorn.tmirah@gene.com

Abstract

BACKGROUND:

The underlying reasons for racial disparities in asthma morbidity are not well understood. Multivariate epidemiologic studies evaluating the presence and extent of racial differences in a large cohort of adults with severe or difficult-to-treat asthma are lacking.

OBJECTIVE:

To analyze an extensive array of clinical and patient-reported outcomes, using multivariate analysis with a sequential approach, to explain racial differences in asthma-related outcomes in one of the largest cohorts of difficult-to-treat asthmatic patients.

METHODS:

Black and white patients (> or = 18-years-old at baseline) were included (n = 2,128). Differences between the 2 racial groups were assessed using several outcome measures at month 12. Assessments were adjusted for confounding variables using a sequence of statistical models.

RESULTS:

Most patients were white (88.6%). Blacks were slightly younger, less educated, and more likely to live in urban areas than whites. Blacks were more likely to have severe asthma and to be treated with 3 or more long-term controllers. Poorer quality of life, more asthma control problems, and higher risk of emergency department visits were observed in blacks compared with whites; differences were not explained by adjustment for broad sets of confounding variables. Differences in asthma-related health outcomes remained statistically significant after adjusting for asthma severity.

CONCLUSIONS:

Asthma is a serious health problem in blacks and is not explained by differences in demographics, severity, or other health conditions.

PMID:
18814448
DOI:
10.1016/S1081-1206(10)60490-5
[Indexed for MEDLINE]

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