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Semin Thromb Hemost. 2008 Jun;34(4):335-9. doi: 10.1055/s-0028-1085475. Epub 2008 Sep 23.

Antiprothrombin antibody testing: detection and clinical utility.

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1
Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Abstract

Anticardiolipin antibody (aCL), anti-beta2 glycoprotein I antibodies, and lupus anticoagulant (LA) are the only laboratory tests considered within the revised criteria for the classification of the antiphospholipid syndrome (APS). Recently, antibodies against phosphatidylserine-prothrombin complex (aPS/PT) have been detected, and these antibodies, rather than antibodies against prothrombin alone, are closely associated with APS and LA. The sensitivity and specificity of aPS/PT for the diagnosis of APS were assessed in a population of patients with a variety of autoimmune disorders. aCL and aPS/PT have similar diagnostic value for APS, therefore aPS/PT should be further explored, not only for research purposes but also as a candidate for one of the laboratory criteria for the classification of the APS.

PMID:
18814066
DOI:
10.1055/s-0028-1085475
[Indexed for MEDLINE]
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