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Magn Reson Med. 1991 Jun;19(2):439-45.

Localized 1H NMR spectroscopy in Canavan's disease: a report of two cases.

Author information

1
Sub-Department of Academic Radiology, Institute of Child Health, London, England.

Abstract

Two children with Canavan's Disease, an autosomal recessive leukodystrophy, were studied by localized 1H spectroscopy. The N-acetylaspartate (NAA) signal intensity was high relative to other metabolite signals, and the signal intensity from choline-containing compounds was low. These findings are discussed in relation to a possible role for NAA in normal myelination.

PMID:
1881331
DOI:
10.1002/mrm.1910190235
[Indexed for MEDLINE]

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