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Nat Rev Mol Cell Biol. 2008 Nov;9(11):910-6. doi: 10.1038/nrm2510. Epub 2008 Sep 24.

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

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Helfrid Hochegger is at the Genome Damage and Stability Centre, University of Sussex, Falmer Brighton, BN1 9RQ, UK.


Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a dominant-negative mutation of CDK1 blocks the cell cycle at G2-M phase, whereas dominant-negative CDK2 inhibits the transition into S phase, a model of cell-cycle control has emerged in which each transition is regulated by a specific subset of CDKs and cyclins. Recent work with gene-targeted mice has led to a revision of this model. We discuss cell-cycle control in light of overlapping and essential functions of the different CDKs and cyclins.

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