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Curr Opin Pulm Med. 2008 Nov;14(6):537-42. doi: 10.1097/MCP.0b013e328312ed61.

The Sleep Heart Health Study: a progress report.

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1
VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts 02118-2394, USA. gottlieb@bu.edu

Abstract

PURPOSE OF REVIEW:

The Sleep Heart Health Study began in 1994 as a prospective cohort study of cardiovascular disease. The results of longitudinal analysis are not yet available, but numerous analyses of cross-sectional data have been published. This review provides an overview of study results so far.

RECENT FINDINGS:

Recent findings covered in this review include a methodological study supporting the choice of a 4% oxyhemoglobin desaturation criterion for identification of hypopneas; evidence that sleepiness may modify the association of sleep apnea with hypertension; the association of sleep apnea with increased left ventricular mass in a pattern suggesting predominantly eccentric left ventricular hypertrophy; the association of restless legs syndrome with an increase in prevalent cardiovascular disease; and the results of a genome-wide association study of sleep and circadian phenotypes.

SUMMARY:

Although designed as a prospective cohort study, analysis of cross-sectional data from the Sleep Heart Health Study has contributed numerous insights to the field of sleep medicine.

PMID:
18812830
DOI:
10.1097/MCP.0b013e328312ed61
[Indexed for MEDLINE]
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