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Toxicon. 2008 Dec 1;52(7):824-8. doi: 10.1016/j.toxicon.2008.08.011. Epub 2008 Sep 5.

Ratio of lethal and edema factors in rabbit systemic anthrax.

Author information

1
Dipartimento di Scienze Biomediche- CNR Istituto di Neuroscienze, viale G. Colombo 3, 35121 Padova, Italy.

Abstract

Bacillus anthracis secretes two binary toxins: lethal toxin (PA + LF) and edema toxin (PA + EF) that play a major role in the pathogenesis of anthrax. Their activities can synergize or interfere among each other, depending on the cell type. It is therefore fundamental to know their concentration ratio in vivo. Here, we report the first determination of the concentration ratio of anthrax toxin components LF/EF in the serum of rabbits infected with B. anthracis spores.

PMID:
18812184
DOI:
10.1016/j.toxicon.2008.08.011
[Indexed for MEDLINE]

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