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Int Arch Occup Environ Health. 2009 Mar;82(4):489-97. doi: 10.1007/s00420-008-0358-5. Epub 2008 Sep 23.

The relationship between malignant mesothelioma and an asbestos cement plant environmental risk: a spatial case-control study in the city of Bari (Italy).

Author information

1
Department of Internal Medicine and Public Medicine, Section of Occupational Medicine Ramazzini, University of Bari, National Register of Mesothelioma, Regional Operative Centre (C.O.R.), Apulia, Italy.

Abstract

OBJECTIVES:

To estimate the mesothelioma risk and environmental asbestos exposure (EAE) due to an asbestos-cement plant.

METHODS:

A spatial case-control study including 48 malignant mesothelioma (MM) cases occurred in the period 1993-2003 selected from the regional mesothelioma register (RMR) and 273 controls. The disease risk was estimated by means of a logistic-regression model, in which the probability of disease-occurrence is expressed as a function of the classes of distances. A non-parametric method was applied to estimate the full relative risk surface.

RESULTS:

Significant MM odds ratio of 5.29 (95 CI: 1.18-23.74) was found for people living within a range up to 500 m centered on the plant. The non-parametric estimation of relative risk surface unveiled a marked peak near the plant not paralleled by the spatial distribution of controls.

CONCLUSION:

Evidence of an association between mesothelioma risk and EAE is highlighted. The role played by the RMR in increasing the public health local authorities awareness is stressed.

PMID:
18810484
DOI:
10.1007/s00420-008-0358-5
[Indexed for MEDLINE]

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