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Antimicrob Agents Chemother. 2008 Dec;52(12):4518-21. doi: 10.1128/AAC.00640-08. Epub 2008 Sep 22.

Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria.

Author information

1
Department of Biomedical Sciences, Florida State University College of Medicine, 1115 West Call Street, Tallahassee, FL 32306-4300, USA. mindy.brown@med.fsu.edu

Abstract

Tet 42, a novel tetracycline resistance determinant from deep subsurface bacteria, was characterized and found to have a 30% sequence similarity to TetA(Z). The protein is a putative efflux pump that shares characteristics with previously characterized pumps, including a divergently transcribed TetR repressor, a conserved GxxSDRxGRR motif, and transmembrane domains.

PMID:
18809935
PMCID:
PMC2592862
DOI:
10.1128/AAC.00640-08
[Indexed for MEDLINE]
Free PMC Article

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