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Am J Transplant. 2008 Nov;8(11):2476-8. doi: 10.1111/j.1600-6143.2008.02405.x. Epub 2008 Sep 19.

Intentional ABO-incompatible lung transplantation.

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Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany.


We report on a case of intentional blood group incompatible lung transplantation. A blood group O cystic fibrosis patient was mechanically ventilated and put on interventional lung assist for severe respiratory decompensation. Since timely allocation of a blood group O donor lung was impossible, an AB deceased donor lung rescue allocation was accepted and the transplant performed using a pre-, peri- and postoperative antibody depletion protocol including plasmapheresis, ivIg administration, rituximab and immunoadsorption. Nine months after the transplant the patient is at home and well.

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