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Infect Control Hosp Epidemiol. 2008 Oct;29(10):975-7. doi: 10.1086/590666.

Coadministration of oral levofloxacin with agents that impair absorption: impact on antibiotic resistance.

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1
Divisions of Infectious Diseases, Departments of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Abstract

Coadministration of oral divalent or trivalent cation-containing compounds with oral fluoroquinolones may impair fluoroquinolone absorption. Among 3,134 patients who received a course of oral levofloxacin, coadministration was significantly associated with subsequent identification of a levofloxacin-resistant isolate. Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation-containing compounds and fluoroquinolone.

PMID:
18808343
DOI:
10.1086/590666
[Indexed for MEDLINE]
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