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J Mater Sci Mater Med. 2009 Jan;20(1):347-50. doi: 10.1007/s10856-008-3588-x. Epub 2008 Sep 21.

Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells.

Author information

1
Department of Orthopedics, Mayo Clinic and Foundation, Rochester, MN 55905, USA. ddmandal@yahoo.com

Abstract

Nanoparticles have been extensively used for a variety of biomedical applications and there is a growing need for highly specific and efficient delivery of the nanoparticles into target cells and subcellular location. We attempted to accomplish this goal by modifying gold particles with peptide motif's that are known to deliver a 'cargo' into chosen cellular location specifically, we intended to deliver nanogold particles into cells through chemical cross-linking with different peptides known to carry protein into cells. Our results suggest that specific sequence of such 'carrier peptides' can efficiently deliver gold nanoparticles into cells when chemically cross-linked with the metal particles.

PMID:
18807262
PMCID:
PMC2824438
DOI:
10.1007/s10856-008-3588-x
[Indexed for MEDLINE]
Free PMC Article

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