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Nat Methods. 2008 Oct;5(10):873-5. doi: 10.1038/nmeth.1254. Epub 2008 Sep 21.

Building consensus spectral libraries for peptide identification in proteomics.

Author information

1
Institute for Systems Biology, Seattle, Washington 98103, USA. kehlam@ust.hk

Abstract

Spectral searching has drawn increasing interest as an alternative to sequence-database searching in proteomics. We developed and validated an open-source software toolkit, SpectraST, to enable proteomics researchers to build spectral libraries and to integrate this promising approach in their data-analysis pipeline. It allows individual researchers to condense raw data into spectral libraries, summarizing information about observed proteomes into a concise and retrievable format for future data analyses.

PMID:
18806791
PMCID:
PMC2637392
DOI:
10.1038/nmeth.1254
[Indexed for MEDLINE]
Free PMC Article

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