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Bioorg Med Chem Lett. 2008 Oct 15;18(20):5523-7. doi: 10.1016/j.bmcl.2008.09.008. Epub 2008 Sep 6.

Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes.

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1
Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology, 150 West University Boulevard, Melbourne, FL 32901, USA.

Abstract

The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF(3alpha)-VI 17 and 8,12-iso-iPF(3alpha)-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid- (EPA) and docosahexaenoic acid- (DHA) enriched phospholipids.

PMID:
18804370
PMCID:
PMC2581611
DOI:
10.1016/j.bmcl.2008.09.008
[Indexed for MEDLINE]
Free PMC Article
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