Format

Send to

Choose Destination
Curr Opin Microbiol. 2008 Oct;11(5):387-92. doi: 10.1016/j.mib.2008.08.002. Epub 2008 Oct 6.

Has nature already identified all useful antibacterial targets?

Author information

1
Infection Biology, Biozentrum, University of Basel, Klingelbergstr. 50/70, CH-4056 Basel, Switzerland. dirk.bumann@unibas.ch

Abstract

Novel antimicrobial targets are urgently needed to overcome rising antibiotic resistance of important human pathogens. However, evidence from previous antimicrobial screenings, in silico analysis, and experimental target evaluation suggests that the number of novel bacterial broad-spectrum targets might be severely limited. This is because of the poor conservation of genes among diverse bacterial pathogens, partial functional redundancy and nutrient-rich host environments. Remaining opportunities under these circumstances include the development of narrow-spectrum antibiotics against specific pathogens and the exploration of target combinations.

PMID:
18804175
DOI:
10.1016/j.mib.2008.08.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center