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Chem Biol. 2008 Sep 22;15(9):879-80. doi: 10.1016/j.chembiol.2008.09.001.

Friend or foe? Turning a host defense protein into a pathogen's accomplice.

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1
Department of Pathology and Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

Abstract

Cystatins are cysteine protease inhibitors that are at the front-line of defense against pathogens that secrete proteases as virulence factors. In this issue, Vincents et al. (2008) reveal how the bacterial protease IdeS from Streptococcus pyogenes hijacks normal cystatin C function to convert it into a cofactor that enhances proteolytic destruction of host-defense antibodies.

PMID:
18804024
DOI:
10.1016/j.chembiol.2008.09.001
[Indexed for MEDLINE]
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