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Expert Rev Mol Med. 2008 Sep 22;10:e27. doi: 10.1017/S1462399408000811.

Recent advances in understanding the molecular basis of group B Streptococcus virulence.

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  • 1Department of Pediatrics, University of California San Diego, La Jolla, CA 92093-0687, USA.

Abstract

Group B Streptococcus commonly colonises healthy adults without symptoms, yet under certain circumstances displays the ability to invade host tissues, evade immune detection and cause serious invasive disease. Consequently, Group B Streptococcus remains a leading cause of neonatal pneumonia, sepsis and meningitis. Here we review recent information on the bacterial factors and mechanisms that direct host-pathogen interactions involved in the pathogenesis of Group B Streptococcus infection. New research on host signalling and inflammatory responses to Group B Streptococcus infection is summarised. An understanding of the complex interplay between Group B Streptococcus and host provides valuable insight into pathogen evolution and highlights molecular targets for therapeutic intervention.

PMID:
18803886
PMCID:
PMC2676346
DOI:
10.1017/S1462399408000811
[PubMed - indexed for MEDLINE]
Free PMC Article
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