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Nat Rev Neurosci. 2008 Oct;9(10):747-58. doi: 10.1038/nrn2493.

CART peptides: regulators of body weight, reward and other functions.

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1
Neuroscience Division, Yerkes National Primate Research Center of Emory University, 954 Gatewood Road NE, Atlanta, Georgia 30329, USA.

Erratum in

  • Nat Rev Neurosci. 2010 Mar;11(3):218. Dosage error in article text.

Abstract

Over the past decade or so, CART (cocaine- and amphetamine-regulated transcript) peptides have emerged as major neurotransmitters and hormones. CART peptides are widely distributed in the CNS and are involved in regulating many processes, including food intake and the maintenance of body weight, reward and endocrine functions. Recent studies have produced a wealth of information about the location, regulation, processing and functions of CART peptides, but additional studies aimed at elucidating the physiological effects of the peptides and at characterizing the CART receptor(s) are needed to take advantage of possible therapeutic applications.

PMID:
18802445
PMCID:
PMC4418456
DOI:
10.1038/nrn2493
[Indexed for MEDLINE]
Free PMC Article
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