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Chem Immunol Allergy. 2008;94:189-200. doi: 10.1159/000155087.

Lung dendritic cells: targets for therapy in allergic disease.

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1
Department of Respiratory Diseases, University Hospital Ghent, Ghent, Belgium. bart.lambrecht@ugent.be

Abstract

Dendritic cells (DCs) are crucial in determining the functional outcome of allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 sensitization typical of allergic disease, whereas antigen presentation by plasmacytoid DCs serves to dampen inflammation. It is increasingly clear that DCs have an antigen presenting function beyond sensitization. DCs therefore constitute a novel target for the development of antiallergic therapy aimed at the origin of the inflammatory cascade. A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel antiallergic compounds.

PMID:
18802348
DOI:
10.1159/000155087
[Indexed for MEDLINE]
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