Format

Send to

Choose Destination
See comment in PubMed Commons below
BMJ. 2008 Sep 18;337:a1343. doi: 10.1136/bmj.a1343.

Pregnancy outcome in women before and after cervical conisation: population based cohort study.

Author information

  • 1Department of Obstetrics and Gynecology, Haukeland University Hospital, Institute of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. Susanne.Albrechtsen@Helse-Bergen.no

Abstract

OBJECTIVES:

To examine the consequences of cervical conisation in terms of adverse outcome in subsequent pregnancies.

DESIGN:

Population based cohort study.

DATA SOURCES:

Data on cervical conisation derived from the Cancer Registry of Norway and on pregnancy outcome from the Medical Birth Registry of Norway, 1967-2003. 15 108 births occurred in women who had previously undergone cervical conisation and 57 136 who subsequently underwent cervical conisation. In the same period there were 2 164 006 births to women who had not undergone relevant treatment (control).

RESULTS:

The proportion of preterm delivery was 17.2% in women who gave birth after cervical conisation versus 6.7% in women who gave birth before cervical conisation and 6.2% in women who had not undergone cervical conisation. The relative risk of a late abortion (<24 weeks' gestation) was 4.0 (95% confidence interval 3.3 to 4.8) in women who gave birth after cervical conisation compared with no cervical conisation. The relative risk of delivery was 4.4 (3.8 to 5.0) at 24-27 weeks, 3.4 (3.1 to 3.7) at 28-32 weeks, and 2.5 (2.4 to 2.6) at 33-36 weeks. The relative risk of preterm delivery declined during the study period and especially of delivery before 28 weeks' gestation.

CONCLUSION:

Cervical conisation influences outcome in subsequent pregnancies in terms of an increased risk of preterm delivery, especially in the early gestational age groups in which the clinical significance is highest. A careful clinical approach should be taken in the selection of women for cervical conisation and in the clinical care of pregnancies after a cervical conisation.

PMID:
18801869
PMCID:
PMC2544429
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center