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Dev Biol. 2008 Nov 15;323(2):197-206. doi: 10.1016/j.ydbio.2008.08.021. Epub 2008 Aug 29.

Differential requirements of a mitotic acetyltransferase in somatic and germ line cells.

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1
Instituto Gulbenkian de Ciência, Rua da Quinta Grande, n 6, 2781-901 Oeiras, Portugal.

Abstract

During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (san). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that san is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion.

PMID:
18801358
PMCID:
PMC2605734
DOI:
10.1016/j.ydbio.2008.08.021
[Indexed for MEDLINE]
Free PMC Article
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