Format

Send to

Choose Destination
Bioessays. 2008 Oct;30(10):929-33. doi: 10.1002/bies.20824.

Feedback-mediated neuronal competition for survival cues regulates innervation of a target tissue.

Author information

1
Program in Neuroscience and Neurobehavior al Disorders, DUKE-National University of Singapore Graduate Medical School, Singapore.

Abstract

Proper wiring of the nervous system requires tight control of the number of nerve terminals that innervate a target tissue. Recent work by Deppmann et al., now suggests that this is achieved by feedback-mediated neuronal competition for target-derived survival cues. The authors' model is inspired by the theory for pattern formation based on self-activation and lateral inhibition, proposed by Meinhardt and Gierer more than 30 years ago.

PMID:
18800366
DOI:
10.1002/bies.20824
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center