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Pharmacol Rep. 2008 Jul-Aug;60(4):574-7.

Clenbuterol enhances the production of kynurenic acid in brain cortical slices and glial cultures.

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1
Department of Pharmacology and Clinical Pharmacology, Skubiszewski Medical School, Jaczewskiego 8, PL 20-090 Lublin, Poland.

Abstract

The effect of a beta(2)-adrenergic agonist, clenbuterol on the production of a glutamate receptor antagonist, kynurenic acid was studied in vitro. Clenbuterol enhanced the production of kynurenic acid in brain cortical slices (0.1-1.0 mM) and in glial cultures (1-50 muM). Timolol, a non-selective beta-adrenergic antagonist prevented this effect. The presented data indicate a novel mechanism of action of beta(2)-adrenoceptor agonists and suggest that an increased formation of the endogenous glutamate receptor antagonist, kynurenic acid could partially contribute to their neuroprotective activity.

PMID:
18799828
[Indexed for MEDLINE]
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